San Francisco vs Arizona Prediction, Game Preview

Darren Yamashita-USA TODAY Sports

San Francisco vs Arizona Prediction, Game Preview


San Francisco vs Arizona Prediction, Game Preview


San Francisco vs Arizona prediction, game preview, how to watch: Sunday, October 10

San Francisco vs Arizona How To Watch

Date: Sunday, October 10
Game Time: 4:25 ET
Venue: State Farm Stadium, Glendale, AZ
How To Watch: FOX
Record: Arizona (4-0), San Francisco (2-2)
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San Francisco vs Arizona Game Preview

Why San Francisco Will Win

Alright, 5. Let’s see what you can do.

The Trey Lance era gets going for real with Jimmy Garoppolo hurting with a leg injury, and he could be exactly what the offense needs against an Arizona defense with a whole lot of athletes and playmakers, but is a tad soft against the run.

Lance won’t be alone. Rookie RB Elijah Mitchell is expected to give it a go after missing time with a shoulder injury, the O line is about as right as it’s been in weeks, and …

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Why Arizona Will Win

Can the 49er defense do anything to stop the machine?

San Francisco doesn’t force takeaways – just one in the opener against Detroit, and that’s it – and Arizona’s D comes up with a whole bunch of big plays.

Lance might be ready to put up some big moments and numbers, but he’s still a rookie – the turnovers will come.

Arizona has forced nine in the first four games, and that might be enough. It doesn’t have to come up with a whole ton of Lance mistakes, but two might do it because …

What’s Going To Happen

There’s no one playing better than Kyler Murray.

He’s got the Arizona offense humming. It’s the best in the NFL with close to 1,800 yards with 31 points or more in every game.

Lance will be good, but the Niners won’t be able to keep up.

San Francisco vs Arizona Prediction, Line

Arizona 31, San Francisco 23
Line: Arizona -5, o/u: 48.5
ATS Confidence out of 5: 3

Get a 2nd opinion on the San Francisco 49ers vs Arizona Cardinals game from our friends at Winners and Whiners. Click here for their in-depth analysis and predictions on the side, total, 1st half, and exotics.

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