The Week 4 college football predictions, TV schedules, game previews and game times, broken down by conference.
All Listed Gametimes EST
Click on each game for game preview & prediction, all published throughout the week.
Week 4 Fearless Predictions, Game Previews
– CFN Fearless Predictions & Game Previews
– Week 4 College Final Thoughts, Betting Advice
– Week 4 Expert Picks & Predictions: College
– Week 3 Expert Picks & Predictions: NFL
– Week 4 10 Best College Picks vs. The Spread
– Week 4 5 Best College Picks: Money Line
ACC
Saturday, September 26
Louisville at Pitt
Line: Pitt -2.5, o/u: 54
Prediction: Pitt 31, Louisville 26
Final Score: Pitt 23, Louisville 20
Georgia Tech at Syracuse
Line: Georgia Tech -8, o/u: 54.5
Prediction: Georgia Tech 23, Syracuse 20
Final Score: Syracuse 37, Georgia Tech 20
Duke at Virginia
Line: Virginia -4, o/u: 45
Prediction: Virginia 23, Duke 16
Final Score: Virginia 38, Duke 20
Texas State at Boston College
Line: Boston College -21, o/u: 57.5
Prediction: Boston College 40, Texas State 17
Final Score: Boston College 24, Texas State 21
Florida State at Miami
Line: Miami -11.5, o/u: 53.5
Prediction: Miami 30, Florida State 17
Final Score: Miami 52, Florida State 10
NC State at Virginia Tech
Line: Virginia Tech -7, o/u: 57
Prediction: Virginia Tech 37, NC State 27
Final Score: Virginia Tech 45, NC State 24
Notre Dame at Wake Forest
POSTPONED
American Athletic
Saturday, September 26
UCF at East Carolina
Line: UCF -27, o/u: 77.5
Prediction: UCF 48, East Carolina 20
Final Score: UCF 51, East Carolina 28
Tulane at Southern Miss
Line: Tulane -3.5, o/u: 54.5
Prediction: Tulane 30, Southern Miss 24
Final Score: Tulane 66, Southern Miss 24
Army at Cincinnati
Line: Cincinnati -12.5, o/u: 45
Prediction: Cincinnati 26, Army 17
Final Score: Cincinnati 24, Army 10
Stephen F. Austin at SMU
7:00 ESPN+
Line: No Line, o/u: No Line
Prediction: SMU 50, Stephen F. Austin 17
Final Score: SMU 50, Stephen F. Austin 7
Tulsa at Arkansas State
POSTPONED
North Texas at Houston
POSTPONED
USF at Florida Atlantic
POSTPONED
Big 12
Saturday, September 26
Kansas State at Oklahoma
Line: Oklahoma -27.5, o/u: 61
Prediction: Oklahoma 40, Kansas State 27
Final Score: Kansas State 38, Oklahoma 35
Iowa State at TCU
Line: Iowa State -4, o/u: 43
Prediction: TCU 23, Iowa State 20
Final Score: Iowa State 37, TCU 34
Texas at Texas Tech
Line: Texas -17.5, o/u: 70.5
Prediction: Texas 44, Texas Tech 24
Final Score: Texas 63, Texas Tech 56 OT
West Virginia at Oklahoma State
Line: Oklahoma State -5.5, o/u: 49.5
Prediction: Oklahoma State 26, West Virginia 20
Final Score: Oklahoma State 27, West Virginia 13
Kansas at Baylor
Line: Baylor -17.5, o/u: 62
Prediction: Baylor 40, Kansas 14
Final Score: Baylor 47, Kansas 14
Conference USA
Thursday, September 24
UAB at South Alabama
Line: UAB -7, o/u: 50
Prediction: UAB 27, South Alabama 23
Final Score: UAB 42, South Alabama 10
Friday, September 25
Middle Tennessee at UTSA
Line: UTSA -5.5, o/u: 59.5
Prediction: UTSA 38, Middle Tennessee 27
Final Score: UTSA 37, Middle Tennessee 35
Saturday, September 26
FIU at Liberty
Line: Liberty -8.5, o/u: 60.5
Prediction: Liberty 34, FIU 27
Final Score: Liberty 36, FIU 34
UTEP at ULM
Line: ULM -9.5, o/u: 50
Prediction: ULM 31, UTEP 14
Final Score: UTEP 31, ULM 6
Tulane at Southern Miss
Line: Tulane -3.5, o/u: 54.5
Prediction: Tulane 30, Southern Miss 24
Final Score: Tulane 66, Southern Miss 24
Houston Baptist at Louisiana Tech
Line: No Line, o/u: No Line
Prediction: Louisiana Tech 52, Houston Baptist 30
Final Score: Louisiana Tech 66, Houston Baptist 38
Georgia State at Charlotte
POSTPONED
USF at Florida Atlantic
POSTPONED
North Texas at Houston
POSTPONED
Independents
Saturday, September 26
FIU at Liberty
Line: Liberty -8.5, o/u: 60.5
Prediction: Liberty 34, FIU 27
Final Score: Liberty 36, FIU 34
Army at Cincinnati
Line: Cincinnati -12.5, o/u: 45
Prediction: Cincinnati 26, Army 17
Final Score: Cincinnati 24, Army 10
Troy at BYU
Line: BYU -14, o/u: 61
Prediction: BYU 40, Troy 17
Final Score: BYU 48, Troy 7
SEC
Saturday, September 26
Florida at Ole Miss
Line: Florida -13.5, o/u: 57.5
Prediction: Florida 30, Ole Miss 13
Final Score: Florida 51, Ole Miss 35
Kentucky at Auburn
Line: Auburn -6.5, o/u: 46.5
Prediction: Auburn 23, Kentucky 17
Final Score: Auburn 29, Kentucky 13
Mississippi State at LSU
Line: LSU -14.5, o/u: 57
Prediction: LSU 34, Mississippi State 23
Final Score: Mississippi State 44, LSU 34
Georgia at Arkansas
Line: Georgia -27.5, o/u: 53
Prediction: Georgia 45, Arkansas 16
Final Score: Georgia 37, Arkansas 10
Alabama at Missouri
Line: Alabama -28.5, o/u: 55.5
Prediction: Alabama 41, Missouri 13
Final Score: Alabama 38, Missouri 19
Vanderbilt at Texas A&M
Line: Texas A&M -31, o/u: 46.5
Prediction: Texas A&M 38, Vanderbilt 13
Final Score: Texas A&M 17, Vanderbilt 12
Tennessee at South Carolina
Line: Tennessee -4.5, o/u: 45
Prediction: South Carolina 24, Tennessee 23
Final Score: Tennessee 31, South Carolina 27
Sun Belt
Thursday, September 24
UAB at South Alabama
Line: UAB -7, o/u: 50
Prediction: UAB 27, South Alabama 23
Final Score: UAB 42, South Alabama 10
Saturday, September 26
Georgia Southern at Louisiana
Line: Louisiana -11.5, o/u: 52
Prediction: Louisiana 34, Georgia Southern 20
Final Score: Louisiana 20, Georgia Southern 18
Campbell at Appalachian State
Line: No Line, o/u: No Line
Prediction: Appalachian State 45, Campbell 10
Final Score: Appalachian State 52, Campbell 21
UTEP at ULM
Line: ULM -9.5, o/u: 50
Prediction: ULM 31, UTEP 14
Final Score: UTEP 31, ULM 6
Texas State at Boston College
Line: Boston College -21, o/u: 57.5
Prediction: Boston College 40, Texas State 17
Final Score: Boston College 24, Texas State 21
Troy at BYU
Line: BYU -14, o/u: 61
Prediction: BYU 40, Troy 17
Final Score: BYU 48, Troy 7
Tulsa at Arkansas State
POSTPONED
Georgia State at Charlotte
POSTPONED
